Subtle Rapid Eye Movement Sleep Abnormalities in Presymptomatic Spinocerebellar Ataxia Type 2 Gene Carriers
Identifieur interne : 001865 ( Main/Exploration ); précédent : 001864; suivant : 001866Subtle Rapid Eye Movement Sleep Abnormalities in Presymptomatic Spinocerebellar Ataxia Type 2 Gene Carriers
Auteurs : Roberto Rodriguez-Labrada [Cuba] ; Luis Velazquez-Perez [Cuba] ; Nalia Canales Ochoa [Cuba] ; Lourdes Galicia Polo [Mexique] ; Reyes Haro Valencia [Mexique] ; Gilberto Sanchez Cruz [Cuba] ; Jacqueline Medrano Montero [Cuba] ; Jose M. Laffita-Mesa [Cuba] ; Luis E. Almaguer Mederos [Cuba] ; Yanetza Gonzalez Zaldivar [Cuba] ; Cira Torres Parra [Cuba] ; Arnoy Pena Acosta [Cuba] ; Tania Cruz Marino [Cuba]Source :
- Movement disorders [ 0885-3185 ] ; 2011.
Descripteurs français
- Pascal (Inist)
English descriptors
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Abstract
Rapid eye movement (REM) sleep disorders are commonly associated to patients with spinocerebellar ataxia type 2 (SCA2); however, these abnormalities have not been studied in presymptomatic gene carriers. To determine whether the REM sleep pathology is detectable before clinical manifestation of SCA2 and evaluate it as a preclinical biomarker, we studied 36 presymptomatic SCA2 individuals and 36 controls by video-polysomnography (VPSG) and sleep questionnaires. Presymptomatic subjects showed significant decrease of REM sleep percentage, REMs density, total sleep time, and sleep efficiency. Aging effect on REM sleep percentage was significant in both groups. There was no correlation between cytosine-adenine-guanine (CAG) repeat length and REM sleep. Our findings identified the REM sleep pathology as a prominent herald sign of SCA2, conferring a special importance to VPSG as a sensitive neurophysiological tool to detect early changes associated with SCA2, which contributes to the understanding of disease pathophysiology and the development of therapeutic trials focused on the preclinical disease stage.
Affiliations:
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">Subtle Rapid Eye Movement Sleep Abnormalities in Presymptomatic Spinocerebellar Ataxia Type 2 Gene Carriers</title><author><name sortKey="Rodriguez Labrada, Roberto" sort="Rodriguez Labrada, Roberto" uniqKey="Rodriguez Labrada R" first="Roberto" last="Rodriguez-Labrada">Roberto Rodriguez-Labrada</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Centre for the Research and Rehabilitation of Hereditary Ataxias</s1><s2>Holguin</s2><s3>CUB</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ></inist:fA14><country>Cuba</country><wicri:noRegion>Centre for the Research and Rehabilitation of Hereditary Ataxias</wicri:noRegion></affiliation></author><author><name sortKey="Velazquez Perez, Luis" sort="Velazquez Perez, Luis" uniqKey="Velazquez Perez L" first="Luis" last="Velazquez-Perez">Luis Velazquez-Perez</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Centre for the Research and Rehabilitation of Hereditary Ataxias</s1><s2>Holguin</s2><s3>CUB</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ></inist:fA14><country>Cuba</country><wicri:noRegion>Centre for the Research and Rehabilitation of Hereditary Ataxias</wicri:noRegion></affiliation></author><author><name sortKey="Canales Ochoa, Nalia" sort="Canales Ochoa, Nalia" uniqKey="Canales Ochoa N" first="Nalia" last="Canales Ochoa">Nalia Canales Ochoa</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Centre for the Research and Rehabilitation of Hereditary Ataxias</s1><s2>Holguin</s2><s3>CUB</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ></inist:fA14><country>Cuba</country><wicri:noRegion>Centre for the Research and Rehabilitation of Hereditary Ataxias</wicri:noRegion></affiliation></author><author><name sortKey="Galicia Polo, Lourdes" sort="Galicia Polo, Lourdes" uniqKey="Galicia Polo L" first="Lourdes" last="Galicia Polo">Lourdes Galicia Polo</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Clinic for Sleep Disorders, Medicine School, UNAM</s1><s2>México DF</s2><s3>MEX</s3><sZ>4 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>Mexique</country><wicri:noRegion>México DF</wicri:noRegion></affiliation></author><author><name sortKey="Haro Valencia, Reyes" sort="Haro Valencia, Reyes" uniqKey="Haro Valencia R" first="Reyes" last="Haro Valencia">Reyes Haro Valencia</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Clinic for Sleep Disorders, Medicine School, UNAM</s1><s2>México DF</s2><s3>MEX</s3><sZ>4 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>Mexique</country><wicri:noRegion>México DF</wicri:noRegion></affiliation></author><author><name sortKey="Sanchez Cruz, Gilberto" sort="Sanchez Cruz, Gilberto" uniqKey="Sanchez Cruz G" first="Gilberto" last="Sanchez Cruz">Gilberto Sanchez Cruz</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Centre for the Research and Rehabilitation of Hereditary Ataxias</s1><s2>Holguin</s2><s3>CUB</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ></inist:fA14><country>Cuba</country><wicri:noRegion>Centre for the Research and Rehabilitation of Hereditary Ataxias</wicri:noRegion></affiliation></author><author><name sortKey="Medrano Montero, Jacqueline" sort="Medrano Montero, Jacqueline" uniqKey="Medrano Montero J" first="Jacqueline" last="Medrano Montero">Jacqueline Medrano Montero</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Centre for the Research and Rehabilitation of Hereditary Ataxias</s1><s2>Holguin</s2><s3>CUB</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ></inist:fA14><country>Cuba</country><wicri:noRegion>Centre for the Research and Rehabilitation of Hereditary Ataxias</wicri:noRegion></affiliation></author><author><name sortKey="Laffita Mesa, Jose M" sort="Laffita Mesa, Jose M" uniqKey="Laffita Mesa J" first="Jose M." last="Laffita-Mesa">Jose M. Laffita-Mesa</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Centre for the Research and Rehabilitation of Hereditary Ataxias</s1><s2>Holguin</s2><s3>CUB</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ></inist:fA14><country>Cuba</country><wicri:noRegion>Centre for the Research and Rehabilitation of Hereditary Ataxias</wicri:noRegion></affiliation></author><author><name sortKey="Almaguer Mederos, Luis E" sort="Almaguer Mederos, Luis E" uniqKey="Almaguer Mederos L" first="Luis E." last="Almaguer Mederos">Luis E. Almaguer Mederos</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Centre for the Research and Rehabilitation of Hereditary Ataxias</s1><s2>Holguin</s2><s3>CUB</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ></inist:fA14><country>Cuba</country><wicri:noRegion>Centre for the Research and Rehabilitation of Hereditary Ataxias</wicri:noRegion></affiliation></author><author><name sortKey="Gonzalez Zaldivar, Yanetza" sort="Gonzalez Zaldivar, Yanetza" uniqKey="Gonzalez Zaldivar Y" first="Yanetza" last="Gonzalez Zaldivar">Yanetza Gonzalez Zaldivar</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Centre for the Research and Rehabilitation of Hereditary Ataxias</s1><s2>Holguin</s2><s3>CUB</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 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Labrada R" first="Roberto" last="Rodriguez-Labrada">Roberto Rodriguez-Labrada</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Centre for the Research and Rehabilitation of Hereditary Ataxias</s1><s2>Holguin</s2><s3>CUB</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ></inist:fA14><country>Cuba</country><wicri:noRegion>Centre for the Research and Rehabilitation of Hereditary Ataxias</wicri:noRegion></affiliation></author><author><name sortKey="Velazquez Perez, Luis" sort="Velazquez Perez, Luis" uniqKey="Velazquez Perez L" first="Luis" last="Velazquez-Perez">Luis Velazquez-Perez</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Centre for the Research and Rehabilitation of Hereditary Ataxias</s1><s2>Holguin</s2><s3>CUB</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ></inist:fA14><country>Cuba</country><wicri:noRegion>Centre for the Research and Rehabilitation of Hereditary Ataxias</wicri:noRegion></affiliation></author><author><name sortKey="Canales Ochoa, Nalia" sort="Canales Ochoa, Nalia" uniqKey="Canales Ochoa N" first="Nalia" last="Canales Ochoa">Nalia Canales Ochoa</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Centre for the Research and Rehabilitation of Hereditary Ataxias</s1><s2>Holguin</s2><s3>CUB</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ></inist:fA14><country>Cuba</country><wicri:noRegion>Centre for the Research and Rehabilitation of Hereditary Ataxias</wicri:noRegion></affiliation></author><author><name sortKey="Galicia Polo, Lourdes" sort="Galicia Polo, Lourdes" uniqKey="Galicia Polo L" first="Lourdes" last="Galicia Polo">Lourdes Galicia Polo</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Clinic for Sleep Disorders, Medicine School, UNAM</s1><s2>México DF</s2><s3>MEX</s3><sZ>4 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>Mexique</country><wicri:noRegion>México DF</wicri:noRegion></affiliation></author><author><name sortKey="Haro Valencia, Reyes" sort="Haro Valencia, Reyes" uniqKey="Haro Valencia R" first="Reyes" last="Haro Valencia">Reyes Haro Valencia</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Clinic for Sleep Disorders, Medicine School, UNAM</s1><s2>México DF</s2><s3>MEX</s3><sZ>4 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>Mexique</country><wicri:noRegion>México DF</wicri:noRegion></affiliation></author><author><name sortKey="Sanchez Cruz, Gilberto" sort="Sanchez Cruz, Gilberto" uniqKey="Sanchez Cruz G" first="Gilberto" last="Sanchez Cruz">Gilberto Sanchez Cruz</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Centre for the Research and Rehabilitation of Hereditary Ataxias</s1><s2>Holguin</s2><s3>CUB</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ></inist:fA14><country>Cuba</country><wicri:noRegion>Centre for the Research and Rehabilitation of Hereditary Ataxias</wicri:noRegion></affiliation></author><author><name sortKey="Medrano Montero, Jacqueline" sort="Medrano Montero, Jacqueline" uniqKey="Medrano Montero J" first="Jacqueline" last="Medrano Montero">Jacqueline Medrano Montero</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Centre for the Research and Rehabilitation of Hereditary Ataxias</s1><s2>Holguin</s2><s3>CUB</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ></inist:fA14><country>Cuba</country><wicri:noRegion>Centre for the Research and Rehabilitation of Hereditary Ataxias</wicri:noRegion></affiliation></author><author><name sortKey="Laffita Mesa, Jose M" sort="Laffita Mesa, Jose M" uniqKey="Laffita Mesa J" first="Jose M." last="Laffita-Mesa">Jose M. Laffita-Mesa</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Centre for the Research and Rehabilitation of Hereditary Ataxias</s1><s2>Holguin</s2><s3>CUB</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ></inist:fA14><country>Cuba</country><wicri:noRegion>Centre for the Research and Rehabilitation of Hereditary Ataxias</wicri:noRegion></affiliation></author><author><name sortKey="Almaguer Mederos, Luis E" sort="Almaguer Mederos, Luis E" uniqKey="Almaguer Mederos L" first="Luis E." last="Almaguer Mederos">Luis E. Almaguer Mederos</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Centre for the Research and Rehabilitation of Hereditary Ataxias</s1><s2>Holguin</s2><s3>CUB</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ></inist:fA14><country>Cuba</country><wicri:noRegion>Centre for the Research and Rehabilitation of Hereditary Ataxias</wicri:noRegion></affiliation></author><author><name sortKey="Gonzalez Zaldivar, Yanetza" sort="Gonzalez Zaldivar, Yanetza" uniqKey="Gonzalez Zaldivar Y" first="Yanetza" last="Gonzalez Zaldivar">Yanetza Gonzalez Zaldivar</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Centre for the Research and Rehabilitation of Hereditary Ataxias</s1><s2>Holguin</s2><s3>CUB</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ></inist:fA14><country>Cuba</country><wicri:noRegion>Centre for the Research and Rehabilitation of Hereditary Ataxias</wicri:noRegion></affiliation></author><author><name sortKey="Torres Parra, Cira" sort="Torres Parra, Cira" uniqKey="Torres Parra C" first="Cira" last="Torres Parra">Cira Torres Parra</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Centre for the Research and Rehabilitation of Hereditary Ataxias</s1><s2>Holguin</s2><s3>CUB</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ></inist:fA14><country>Cuba</country><wicri:noRegion>Centre for the Research and Rehabilitation of Hereditary Ataxias</wicri:noRegion></affiliation></author><author><name sortKey="Pena Acosta, Arnoy" sort="Pena Acosta, Arnoy" uniqKey="Pena Acosta A" first="Arnoy" last="Pena Acosta">Arnoy Pena Acosta</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Centre for the Research and Rehabilitation of Hereditary Ataxias</s1><s2>Holguin</s2><s3>CUB</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ></inist:fA14><country>Cuba</country><wicri:noRegion>Centre for the Research and Rehabilitation of Hereditary Ataxias</wicri:noRegion></affiliation></author><author><name sortKey="Cruz Marino, Tania" sort="Cruz Marino, Tania" uniqKey="Cruz Marino T" first="Tania" last="Cruz Marino">Tania Cruz Marino</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Centre for the Research and Rehabilitation of Hereditary Ataxias</s1><s2>Holguin</s2><s3>CUB</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ></inist:fA14><country>Cuba</country><wicri:noRegion>Centre for the Research and Rehabilitation of Hereditary Ataxias</wicri:noRegion></affiliation></author></analytic><series><title level="j" type="main">Movement disorders</title><title level="j" type="abbreviated">Mov. disord.</title><idno type="ISSN">0885-3185</idno><imprint><date when="2011">2011</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Movement disorders</title><title level="j" type="abbreviated">Mov. disord.</title><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Carrier</term><term>Nervous system diseases</term><term>Rapid eye movement sleep</term><term>Sleep disorder</term><term>Spinocerebellar ataxia</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Trouble du sommeil</term><term>Pathologie du système nerveux</term><term>Sommeil paradoxal</term><term>Ataxie spinocérébelleuse</term><term>Porteur</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Rapid eye movement (REM) sleep disorders are commonly associated to patients with spinocerebellar ataxia type 2 (SCA2); however, these abnormalities have not been studied in presymptomatic gene carriers. To determine whether the REM sleep pathology is detectable before clinical manifestation of SCA2 and evaluate it as a preclinical biomarker, we studied 36 presymptomatic SCA2 individuals and 36 controls by video-polysomnography (VPSG) and sleep questionnaires. Presymptomatic subjects showed significant decrease of REM sleep percentage, REMs density, total sleep time, and sleep efficiency. Aging effect on REM sleep percentage was significant in both groups. There was no correlation between cytosine-adenine-guanine (CAG) repeat length and REM sleep. Our findings identified the REM sleep pathology as a prominent herald sign of SCA2, conferring a special importance to VPSG as a sensitive neurophysiological tool to detect early changes associated with SCA2, which contributes to the understanding of disease pathophysiology and the development of therapeutic trials focused on the preclinical disease stage.</div></front></TEI><affiliations><list><country><li>Cuba</li><li>Mexique</li></country></list><tree><country name="Cuba"><noRegion><name sortKey="Rodriguez Labrada, Roberto" sort="Rodriguez Labrada, Roberto" uniqKey="Rodriguez Labrada R" first="Roberto" last="Rodriguez-Labrada">Roberto Rodriguez-Labrada</name></noRegion><name sortKey="Almaguer Mederos, Luis E" sort="Almaguer Mederos, Luis E" uniqKey="Almaguer Mederos L" first="Luis E." last="Almaguer Mederos">Luis E. Almaguer Mederos</name><name sortKey="Canales Ochoa, Nalia" sort="Canales Ochoa, Nalia" uniqKey="Canales Ochoa N" first="Nalia" last="Canales Ochoa">Nalia Canales Ochoa</name><name sortKey="Cruz Marino, Tania" sort="Cruz Marino, Tania" uniqKey="Cruz Marino T" first="Tania" last="Cruz Marino">Tania Cruz Marino</name><name sortKey="Gonzalez Zaldivar, Yanetza" sort="Gonzalez Zaldivar, Yanetza" uniqKey="Gonzalez Zaldivar Y" first="Yanetza" last="Gonzalez Zaldivar">Yanetza Gonzalez Zaldivar</name><name sortKey="Laffita Mesa, Jose M" sort="Laffita Mesa, Jose M" uniqKey="Laffita Mesa J" first="Jose M." last="Laffita-Mesa">Jose M. Laffita-Mesa</name><name sortKey="Medrano Montero, Jacqueline" sort="Medrano Montero, Jacqueline" uniqKey="Medrano Montero J" first="Jacqueline" last="Medrano Montero">Jacqueline Medrano Montero</name><name sortKey="Pena Acosta, Arnoy" sort="Pena Acosta, Arnoy" uniqKey="Pena Acosta A" first="Arnoy" last="Pena Acosta">Arnoy Pena Acosta</name><name sortKey="Sanchez Cruz, Gilberto" sort="Sanchez Cruz, Gilberto" uniqKey="Sanchez Cruz G" first="Gilberto" last="Sanchez Cruz">Gilberto Sanchez Cruz</name><name sortKey="Torres Parra, Cira" sort="Torres Parra, Cira" uniqKey="Torres Parra C" first="Cira" last="Torres Parra">Cira Torres Parra</name><name sortKey="Velazquez Perez, Luis" sort="Velazquez Perez, Luis" uniqKey="Velazquez Perez L" first="Luis" last="Velazquez-Perez">Luis Velazquez-Perez</name></country><country name="Mexique"><noRegion><name sortKey="Galicia Polo, Lourdes" sort="Galicia Polo, Lourdes" uniqKey="Galicia Polo L" first="Lourdes" last="Galicia Polo">Lourdes Galicia Polo</name></noRegion><name sortKey="Haro Valencia, Reyes" sort="Haro Valencia, Reyes" uniqKey="Haro Valencia R" first="Reyes" last="Haro Valencia">Reyes Haro Valencia</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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|texte= Subtle Rapid Eye Movement Sleep Abnormalities in Presymptomatic Spinocerebellar Ataxia Type 2 Gene Carriers
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